Japanese scientists create vaccine for aging to eliminate aged cells, reversing artery stiffening, frailty, and diabetes in normal and accelerated aging mice

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https://www.nature.com/articles/s43587-021-00151-2

It inhibits anti-apoptotic pathways, meaning it potentially causes cell death in places other than just cancer.

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The main side effect is having to work an extra 20-30 years.

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Let the Umbrella Corp. keep the side effects secret. They aren’t hiding anything

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TLDR:

Can I get a TLDR for the TLDR?

Here is a English translation of a much more detailed article from the Juntendo university:

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World: “Japan, you are getting too old. Nothing you can do about that.”

Why try to solve issues with society and work culture when you can just become elves.

I don’t really see how opening the flood gates would help their situation, they need to incentivize and make having children easier on potential parents.

Where can we find the original paper, with the actual data etc?

OP linked it in their comment

Paywalled:

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Inject this directly into my veins bro

Scientist have been increasing mouse lifespans in various experiments for decades. Temper your expectations.

i'm 69 years old, and that is the best news i've heard in a long time.

As far as the article says , this does NOT give longer lifespan , just reduces the effects of aging. You will live the same amount of time , just in sligthly better shape. It's kind of a cancer vaccine too.

When you say "you would live the same amount of time" what do you actually mean though? If it's kind of a cancer vaccine then someone who would otherwise die at 60 from cancer may live to 80. By eliminating certain effects of aging aren't you potentially lengthening your lifespan by removing the thing which may have caused your death?

It's impossible to say that it will or will not extend human lifespan, as that info is only attainable through human studies. Many people die from effects of aging, cancer, arterial issues, etc. So it would be odd if lifespan was unaffected.

Reducing the effects of aging gives you a longer life span. Nobody has ever actually died of "old age". Old age has made them more susceptible to death from injury or disease, and this vaccine will make both less likely to kill you as you'll be healthier in general.

I have problems with having problems with widespread adoption if not.

So my gf can just get a shot instead of spending tons on beauty treatments?

Well I think that’s just perfect!

Well that sound absolutely amazing. I hope it works out.

Widespread adoption would be amazing, but I think most of us wouldn't be able to afford it.

I don’t think anyone cares if you see no problems in the widespread adoption. No need to close with that.

It does though?

it's nice to see medical science move from lifespan extension to health extension

Lifespan extension is a side effect of being healthy for longer.

This is what mainstream medicine is missing.

Reversing is the word im interested

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Oh herald, begin the age of elves.

I volunteer for human trials

It would be so good. Honestly. I’m in my 60s, I just ache for no reason sometimes. I try to limit the OTC nsaids because I know they aren’t good for me. But aging is painful. Both my parents are gone and they both suffered. I know what is coming. If I could stay healthy until my body gives out, that would be ideal. I don’t mind death. It’s the pain and suffering of growing old that I would like to minimize.

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I wonder how many people would refuse this vaccine

Honestly, i'm okay with them missing out on this one.

We should start tracking religious exemptions now to make sure they don’t accidentally get this one when it comes out.

So you’re saying this is the one we need to put the microchip in…

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If it is properly studied and tested out like polio, measly... vaccine, then I would say hardly anyone.

Only 5% of your cells being quiescent causes you to look like an old person. I know a few researchers who have been working on and funding this research (not this exact vaccine) for the last 10 years. From what they’re saying if the “vaccine” works it would essentially reverse your appearance inward and outward to that of a early 20’s year-old.

So if this becomes public when I’m 50 I could reverse myself back to looking early 20s?

Clearing senescent cells doesn’t put you magically back to young adulthood. They’ve made genetically modified mice that have senescent cells they can kill with a simple switch, and removing them certainly increases their health span, but it doesn’t remove all the other 8-ish hallmarks or aging.

I would love to get this for my dog.

There are two projects aiming to increase healthspan in dogs you might be interested in:

Now Japan will have its ageing workforce forever

If this is feasible and increases age as a side effect, we won't ever see retirement.

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That's cool, but the million dollar question is when will it be available for normal people.

It will delay retirement age and ease the problem of aging population, so I think it will given to normal people given it will make money for them.

The billionaires will be our guinea pigs

Probably, yes. Something like this is far too major to be paywalled and no one will be okay with not having it. Cancer treatment can be paywalled because "Getting cancer" is something we just don't really care enough collectively about until it's personal to us (speaking broadly; I'm sure plenty of people care deeply about cancer, it's just not enough of us at once).

Depends on how effective the final product will be. If it makes a 60 year old as healthy as a 30 year old, I think the price tag at first will be quite high, at least until they deplete the top 1% earners of the population. After that, the price tag will still be high, but achievable. Would you pay $50k to have that privilege, even if you had to save up for 20 years? I know I would. As for the timescale? Who knows, but I definitely think it's doable during our current lifespan (at least for 30-40 year olds and under).

Hasn't this already been invented? Several years ago, a team discovered the same thing.

NAD+ precursors is different from clearing senescent cells. NAD+ precursors was exciting for some a while ago but likely won't pan out.

If we somehow manage to perfect this tech, I wonder what kind of stress would this put on our resources.

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World population is already projected to start dropping by 2050, especially in western world. All we need to do is maximalize education and healthcare in developing world and we should be fine.

Honestly, noone knows. Short term probably a significant strain, long term, probably minimal impact due to lower family sizes. That said, if this technology was put in place in an area with a growing population, then there would be a significant impact.

Very hard to know. Whenever medical outcomes markedly improve in countries, birth rates go down commensurately. You can't just assume that everything would be the same except people dying later.

It mentions it doesn't impact life span, only minimizes the effects of aging. So, you'd be 80 and look like you're 70 with better heart function, etc.

No way to tell for sure.

I think it might have a positive effect. At the moment humans only make decisions and plans regarding things that are happening soon. Our relatively short lifespans make it easy to disregard and care less about everything that might happen after we die. Why plant an oak tree today if it will only be fully grown after I'm dead? Why care about the environment if I can live rich right now, climate change probably won't affect me, right? Maybe we'll start living and making decisions in a more long term way. It might shift our perspectives completely and change us as a species.

The rich consume the vast majority of stuff, if their numbers stay stagnant then it won't have much impact on resources

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Seems like I’m about ten years to old to get advantages of the new fountain of youth that seems to be coming.

don't worry, it's

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Side-effects include looking younger than Anti-vaxxers. Into it

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It's almost better being a mouse at this point.

How soon can I take this ?

Damn, if only I had been born a mouse. I could live forever!

This only aggravates my already annoying mouse envy

This vaccine isn’t under the Warp Speed program so it may be approved for general use in about 20 years.

Apparently fasting kills old cells too. Additionally keeping your hormone levels up after 35yo helps too. These 2 things are crazy powerful.

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They are triggering an immune response to a specific marker that is higher in a specific type of age related cell type. The immune system then goes around killing the age related cells.

Vaccines aren’t always using dead viruses.

They did change the definition within the past couple years.

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Goddamn mice are going to live forever.

Combined with everything else we successfully test on them, supermice will rule the earth

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It makes no sense for a company producing these vaccines offering only to the ultra rich.

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The same people that believe COVID is fake probably gonna jump all over this and be waiting in line for the trials signup like it was an iPhone release.

Just go on Parler or whatever social media site they're using now and start a rumor that it's the newest way the gub'mint is disguising the COVID vaccine (with tracking chips), and if they take this new treatment, that means they're getting the vaccine.

I literally joked about immortal mice on this sub reddit a few days ago.

Would you mind joking about me coming into a lot of money sometime soon?

This is weird - the mice also started dressing hipper and regained their interest in new music.

Might be commenting a bit late but I'm currently listening to the book Lifespan by David Sinclair and the entire premise of the book is exactly this. Anyone interested in this article should definitely give the book a look.

If this is used on boomers they’re evil scientists

Sadly if this thing works as well as they are suggesting, some pharma company will just by the rights and charge insane costs for it.

So... are we going to live forever!?

Sign me up for trials

How long til this gets added to the QR code?

Thank God it’s a vaccine, all the stupid people won’t get it

Smart calling it a vaccine. That way American hicks won't take it.

Great future generations will age slower while I just die ….

Here comes the singularity

vaccines against aging? the future is on its way

Am I gonna live until immortality is invented?!

Just came here from a TIL about a cancer treatment that has a side effect of causing the retina to be sensitive to higher wavelengths. I want this treatment as well.

I’ll take two please. Thanks.

Another giant leap for mouse kind.

Wow this is next level. One step closer to the fountain of youth.

Finally I can live long enough to finish that novel I've been working on

And the Republicans would probably refuse to take this vaccine as well.

See, I told you they’d figure this out before I got old.

Will the country that makes an anti-ageing vaccine become very rich?

And this will all be rolled out to the public the day after I die.

Everything works on mice

I bet those antivaxers will be lining up for this one though!

Wealthy antivax boomers really punching the air rn

How much longer did they live?

Okay. How do we get this?

What a time to be a mouse

It's a great time to be a mouse.

Finally we can die young in car accidents

I’ve read that many scientist believe that the first person who will live 150 has already been born. I Suppose advances and studies like this are what is driving that sentiment.

Yep. I'll take that one without debate.

I feel a little better.

I fear that I was born one or two generations too early

I'll be lookin' like I'm 30 the rest of my life and anti-vaxxers will be lookin' like they 200.

Man, what a time to be a mouse. Cure cancer, reverse aging, mind meld with computers.

This is the first step to me becoming the world's greatest super villain

Is there an immunologist here that can explain something to me?

Age isn't what's got me tired. It's experience.

I need this for my elderly mice.

Ah, so this explains the news post I read yesterday about the Queen

Wish I could be the human test subject

Aging will be a myth in a about 20 years. Too bad I’ll be long gone.

It seems appropriate it would be the Japanese who created this

This is by far one of the most exciting posts for me. Antiaging is one of my favorite areas of research. This is the next step for science. Bookmarked, gonna spend my weekend on this.

Can anyone chime in this research with David Sinclairs work

Why are we calling these vaccines aren’t they gene editing?

No. They are triggering an immune response to a specific cell type that increases with age. The immune system then kills these age related cells.

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I've seen this one.

Fantastic movie... They sure dont make them like they used to...

This feels like a 'Children of Man' precurser....

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The headlines is potentially misleading because it is qualitative in nature. Nevertheless, looking forward for such advancement in science rapidly adopted by many

If this makes it to the US it’ll be $400,000 per shot guaranteed.

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Great, now the boomers will live forever and I will never own a house.

Newsflash- it will be so expensive you can’t afford it

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Soon available in US for 10,000,000 a dose.